作者
Malek ZO Hassan, Magid Awadalla, Timothy C Tan, Marielle Scherrer-Crosbie, Rula Bany Bakar, Zsofia D Drobni, Azmaeen Zarif, Hannah K Gilman, Sama Supraja, Sofia Nikolaidou, Lili Zhang, Daniel A Zlotoff, Shea B Hickey, Sagar A Patel, James L Januzzi, Florence Keane, Jonathon J Passeri, Tomas G Neilan, Shannon M MacDonald, Rachel B Jimenez
发表日期
2023/2/1
期刊
International Journal of Radiation Oncology* Biology* Physics
卷号
115
期号
2
页码范围
398-406
出版商
Elsevier
简介
Purpose
Conventional photon radiation therapy (RT) for breast cancer is associated with a reduction in global longitudinal strain (GLS) and an increase in troponin, N-terminal pro hormone B-type natriuretic peptide (NT-proBNP), and incident heart failure. The cardiac radiation exposure with proton-RT is much reduced and thus may be associated with less cardiotoxicity. The objective was to test the effect of proton-RT on GLS, troponin, and NT-proBNP.
Methods and Materials
We conducted a prospective, observational, single-center study of 70 women being treated with proton-RT for breast cancer. Serial measurements of GLS, high-sensitivity troponin I, and NT-proBNP were performed at prespecified intervals (before proton-RT, 4 weeks after completion of proton-RT, and again at 2 months after proton-RT).
Results
The mean age of the patients was 46 ± 11 years, and the mean body mass index was 25.6 ± 5.2 kg/m2 …
学术搜索中的文章
MZO Hassan, M Awadalla, TC Tan, M Scherrer-Crosbie… - International Journal of Radiation Oncology* Biology …, 2023