作者
Dahlia Banerji, Raza M Alvi, Maryam Afshar, Noor Tariq, Adam Rokicki, Connor P Mulligan, Lili Zhang, Malek O Hassan, Magid Awadalla, John D Groarke, Tomas G Neilan
发表日期
2019/9
期刊
JACC: Heart Failure
卷号
7
期号
9
页码范围
771-778
出版商
American College of Cardiology Foundation
简介
Objectives
This study sought to assess the safety of carvedilol therapy among heart failure (HF) patients with a cocaine-use disorder (CUD).
Background
Although carvedilol therapy is recommended among certain patients with HF, the safety and efficacy of carvedilol among HF patients with a CUD is unknown.
Methods
This was a single-center study of hospitalized patients with HF. Cocaine use was self-reported or defined as having a positive urine toxicology. Patients were divided by carvedilol prescription. Subgroup analyses were performed by strata of ejection fraction (EF) ≤40%, 41% to 49%, or ≥50%. Major adverse cardiovascular events (MACE) were defined as cardiovascular mortality and 30-day HF readmission.
Results
From a cohort of 2,578 patients hospitalized with HF in 2011, 503 patients with a CUD were identified, among whom 404 (80%) were prescribed carvedilol, and 99 (20%) were not. Both …
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D Banerji, RM Alvi, M Afshar, N Tariq, A Rokicki… - JACC: Heart Failure, 2019