作者
Daniel A Zlotoff, Malek ZO Hassan, Amna Zafar, Raza M Alvi, Magid Awadalla, Syed S Mahmood, Lili Zhang, Carol L Chen, Stephane Ederhy, Ana Barac, Dahlia Banerji, Maeve Jones-O'Connor, Sean P Murphy, Merna Armanious, Brian J Forrestal, Michael C Kirchberger, Otavio R Coelho-Filho, Muhammad A Rizvi, Gagan Sahni, Anant Mandawat, Carlo G Tocchetti, Sarah Hartmann, Hannah K Gilman, Eduardo Zatarain-Nicolás, Michael Mahmoudi, Dipti Gupta, Ryan Sullivan, Sarju Ganatra, Eric H Yang, Lucie M Heinzerling, Franck Thuny, Leyre Zubiri, Kerry L Reynolds, Justine V Cohen, Alexander R Lyon, John Groarke, Paaladinesh Thavendiranathan, Anju Nohria, Michael G Fradley, Tomas G Neilan
发表日期
2021
期刊
Journal for immunotherapy of cancer
卷号
9
期号
3
出版商
BMJ Publishing Group
简介
Background
Myocarditis is a highly morbid complication of immune checkpoint inhibitor (ICI) use that remains inadequately characterized. The QRS duration and the QTc interval are standardized electrocardiographic measures that are prolonged in other cardiac conditions; however, there are no data on their utility in ICI myocarditis.
Methods
From an international registry, ECG parameters were compared between 140 myocarditis cases and 179 controls across multiple time points (pre-ICI, on ICI prior to myocarditis, and at the time of myocarditis). The association between ECG values and major adverse cardiac events (MACE) was also tested.
Results
Both the QRS duration and QTc interval were similar between cases and controls prior to myocarditis. When compared with controls on an ICI (93±19 ms) or to baseline prior to myocarditis (97±19 ms), the QRS duration prolonged with myocarditis (110±22 ms, p< 0.001 …
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DA Zlotoff, MZO Hassan, A Zafar, RM Alvi, M Awadalla… - Journal for immunotherapy of cancer, 2021