作者
Syed S Mahmood, Michael G Fradley, Justine V Cohen, Anju Nohria, Kerry L Reynolds, Lucie M Heinzerling, Ryan J Sullivan, Rongras Damrongwatanasuk, Carol L Chen, Dipti Gupta, Michael C Kirchberger, Magid Awadalla, Malek ZO Hassan, Javid J Moslehi, Sachin P Shah, Sarju Ganatra, Paaladinesh Thavendiranathan, Donald P Lawrence, John D Groarke, Tomas G Neilan
发表日期
2018/4/24
期刊
Journal of the American College of Cardiology
卷号
71
期号
16
页码范围
1755-1764
出版商
American College of Cardiology Foundation
简介
Background
Myocarditis is an uncommon, but potentially fatal, toxicity of immune checkpoint inhibitors (ICI). Myocarditis after ICI has not been well characterized.
Objectives
The authors sought to understand the presentation and clinical course of ICI-associated myocarditis.
Methods
After observation of sporadic ICI-associated myocarditis cases, the authors created a multicenter registry with 8 sites. From November 2013 to July 2017, there were 35 patients with ICI-associated myocarditis, who were compared to a random sample of 105 ICI-treated patients without myocarditis. Covariates of interest were extracted from medical records including the occurrence of major adverse cardiac events (MACE), defined as the composite of cardiovascular death, cardiogenic shock, cardiac arrest, and hemodynamically significant complete heart block.
Results
The prevalence of myocarditis was 1.14% with a median time of onset of …
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SS Mahmood, MG Fradley, JV Cohen, A Nohria… - Journal of the American College of Cardiology, 2018