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This scoping review aimed to explore existing literature regarding the work-related stress of people with disabilities and its associated factors. The authors based their research on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines scoping review extension. A total of 26 articles met the inclusion criteria. Results indicated that workplace characteristics, employee differences, work relations, and personal coping strategies were associated with work-related stress. Understanding the nature of work-related stress in people with disabilities is essential to increase these employees' wellbeing and encourage them to stay at work.