作者
Harry Sokol, Philippe Seksik, Lionel Rigottier-Gois, Christophe Lay, Patricia Lepage, Isabelle Podglajen, Philippe Marteau, Joël Doré
发表日期
2006/2/1
期刊
Inflammatory bowel diseases
卷号
12
期号
2
页码范围
106-111
出版商
Oxford University Press
简介
Background
Abnormalities have been described in the fecal microbiota of patients with IBD, but it is not known whether they are specific for inflammatory bowel disease (IBD) or to some extent common to other forms of colitis. The aim of this study was to compare the bacterial composition of the dominant fecal microbiota in patients with Crohn's disease (CD), ulcerative colitis (UC), infectious colitis (IC), and in healthy subjects (HS).
Methods
Fluorescent in situ hybridization adapted to flow cytometry was used to analyze the bacterial composition of fecal samples from 13 patients with active CD, 13 patients with active UC, 5 patients with IC, and 13 HS. We used 6 group-specific probes targeting 16S rRNA and spanning the main phylogenetic groups of the fecal microbiota.
Results
A significantly higher proportion of the total fecal bacteria were recognized by the 6 …
引用总数
学术搜索中的文章
H Sokol, P Seksik, L Rigottier-Gois, C Lay, P Lepage… - Inflammatory bowel diseases, 2006