作者
Anastasiia Gusach, Ivan Maslov, Aleksandra Luginina, Valentin Borshchevskiy, Alexey Mishin, Vadim Cherezov
发表日期
2020/8/1
来源
Current Opinion in Structural Biology
卷号
63
页码范围
18-25
出版商
Elsevier Current Trends
简介
Highlights
- GPCRs are highly dynamic proteins that sample multiple conformational states.
- Dynamic behavior of GPCRs can be described using the concept of energy landscapes.
- Understanding signaling mechanisms requires both structure and dynamics.
- New approaches uncover GPCR dynamics in population and at a single molecule level.
G protein-coupled receptors (GPCRs) constitute the largest superfamily of membrane proteins that are involved in regulation of sensory and physiological processes and implicated in many diseases. The last decade revolutionized the GPCR field by unraveling multiple high-resolution structures of many different receptors in complexes with various ligands and signaling partners. A complete understanding of the complex nature of GPCR function is, however, impossible to attain without combining static structural snapshots with information about GPCR dynamics obtained by …
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A Gusach, I Maslov, A Luginina, V Borshchevskiy… - Current Opinion in Structural Biology, 2020