作者
Adnan K Chhatriwalla, Stephen J Nicholls, Thomas H Wang, Kathy Wolski, Ilke Sipahi, Tim Crowe, Paul Schoenhagen, Samir Kapadia, E Murat Tuzcu, Steven E Nissen
发表日期
2009/3/31
期刊
Journal of the American College of Cardiology
卷号
53
期号
13
页码范围
1110-1115
出版商
American College of Cardiology Foundation
简介
Objectives
We investigated coronary atheroma progression in patients with low levels of low-density lipoprotein cholesterol (LDL-C) and systolic blood pressure (SBP).
Background
Low LDL-C and SBP beneficially impact coronary atherosclerosis. However, the association between intensive control of both risk factors and coronary plaque progression remains unclear.
Methods
Changes in atheroma burden monitored by intravascular ultrasound were studied in 3,437 patients with coronary artery disease (CAD) who were stratified according to on-treatment LDL-C and SBP.
Results
Patients with very low LDL-C (≤70 mg/dl) and normal SBP (≤120 mm Hg) had less progression in percent atheroma volume (PAV) (p < 0.001) and total atheroma volume (TAV) (p < 0.001), more frequent plaque regression (p = 0.01), and less frequent plaque progression (p < 0.001). In patients with SBP >120 mm Hg, very low LDL-C was …
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AK Chhatriwalla, SJ Nicholls, TH Wang, K Wolski… - Journal of the American College of Cardiology, 2009