作者
Ilke Sipahi, E Murat Tuzcu, Katherine E Wolski, Stephen J Nicholls, Paul Schoenhagen, Bo Hu, Craig Balog, Mehdi Shishehbor, William A Magyar, Timothy D Crowe, Samir Kapadia, Steven E Nissen
发表日期
2007/7/3
期刊
Annals of internal medicine
卷号
147
期号
1
页码范围
10-18
出版商
American College of Physicians
简介
Background
In patients with myocardial infarction, β-adrenergic blockers reduce recurrent myocardial infarction and total mortality rates. However, whether a direct influence of β-blockers on coronary atherosclerosis contributes to reduced recurrent myocardial infarction and total mortality rates is not known.
Objective
To assess whether β-blocker therapy is associated with reduced atheroma progression in adults with known coronary artery disease.
Design
Post hoc, pooled analysis of individual patient data from 4 intravascular ultrasonography (IVUS) trials.
Setting
Four IVUS trials conducted in the United States, Europe, and Australia.
Patients
1515 patients with coronary artery disease.
Intervention
The original trials used 3 different statins, a …
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I Sipahi, EM Tuzcu, KE Wolski, SJ Nicholls… - Annals of internal medicine, 2007