作者
Stephen J Nicholls, E Murat Tuzcu, Ilke Sipahi, Paul Schoenhagen, Tim Crowe, Samir Kapadia, Steven E Nissen
发表日期
2006/3/7
期刊
Journal of the American College of Cardiology
卷号
47
期号
5
页码范围
992-997
出版商
American College of Cardiology Foundation
简介
Objectives
The aim of this study was to determine the relationship between atheroma regression and arterial wall remodeling.
Background
Infusion of reconstituted high-density lipoprotein (rHDL) containing recombinant apolipoprotein A-I Milano (AIM) has been reported to promote rapid regression of coronary atherosclerosis. The current study analyzed intravascular ultrasound (IVUS) to define the changes that take place in the arterial wall that accompanied atheroma regression in this study.
Methods
Forty-seven patients, ages 30 to 75 years, after an acute coronary syndrome were randomized to receive five weekly infusions of placebo or rHDL containing either low- or high-dose AIM. External elastic membrane (EEM) and lumen volumes were compared between coronary IVUS studies at baseline and follow-up.
Results
In comparison with baseline, infusion of rHDL was associated with a 4.6% reduction in EEM …
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