作者
Marian Suarez-Gestal, Manuel Calaza, Emoke Endreffy, Rudolf Pullmann, Josep Ordi-Ros, Gian Domenico Sebastiani, Sarka Ruzickova, Maria Jose Santos, Chryssa Papasteriades, Maurizio Marchini, Fotini N Skopouli, Ana Suarez, Francisco J Blanco, Sandra D'Alfonso, Marc Bijl, Patricia Carreira, Torsten Witte, Sergio Migliaresi, Juan J Gomez-Reino, Antonio Gonzalez
发表日期
2009/5/14
期刊
Arthritis research and therapy
卷号
11
期号
3
页码范围
R69
简介
Introduction
We aimed to replicate association of newly identified systemic lupus erythematosus (SLE) loci.
Methods
We selected the most associated SNP in 10 SLE loci. These 10 SNPs were analysed in 1,579 patients with SLE and 1,726 controls of European origin by single-base extension. Comparison of allele frequencies between cases and controls was done with the Mantel–Haenszel approach to account for heterogeneity between sample collections.
Results
A previously controversial association with a SNP in the TYK2 gene was replicated (odds ratio (OR) = 0.79, P = 2.5 × 10-5), as well as association with the X chromosome MECP2 gene (OR = 1.26, P = 0.00085 in women), which had only been reported in a single study, and association with four other loci, 1q25.1 (OR = 0.81, P = 0.0001), PXK (OR = 1.19, P …
引用总数
学术搜索中的文章
M Suarez-Gestal, M Calaza, E Endreffy, R Pullmann… - Arthritis research & therapy, 2009