作者
Evangelos Evangelou, Ana M Valdes, Hanneke JM Kerkhof, Unnur Styrkarsdottir, YanYan Zhu, Ingrid Meulenbelt, Rik J Lories, Fotini B Karassa, Przemko Tylzanowski, Steffan D Bos, Toru Akune, Nigel K Arden, Andrew Carr, Kay Chapman, L Adrienne Cupples, Jin Dai, Panos Deloukas, Michael Doherty, Sally Doherty, Gunnar Engstrom, Antonio Gonzalez, Bjarni V Halldorsson, Christina L Hammond, Deborah J Hart, Hafdis Helgadottir, Albert Hofman, Shiro Ikegawa, Thorvaldur Ingvarsson, Qing Jiang, Helgi Jonsson, Jaakko Kaprio, Hiroshi Kawaguchi, Kalle Kisand, Margreet Kloppenburg, Urho M Kujala, L Stefan Lohmander, John Loughlin, Frank P Luyten, Akihiko Mabuchi, Andrew McCaskie, Masahiro Nakajima, Peter M Nilsson, Nao Nishida, William ER Ollier, Kalliope Panoutsopoulou, Tom Van de Putte, Stuart H Ralston, Fernado Rivadeneira, Janna Saarela, Stefan Schulte-Merker, Dongquan Shi, P Eline Slagboom, Akihiro Sudo, Agu Tamm, Ann Tamm, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Aspasia Tsezou, Gillian A Wallis, J Mark Wilkinson, Noriko Yoshimura, Eleftheria Zeggini, Guangju Zhai, Feng Zhang, Ingileif Jonsdottir, Andre G Uitterlinden, David T Felson, Joyce B van Meurs, Kari Stefansson, John PA Ioannidis, Timothy D Spector
发表日期
2011/2/1
期刊
Annals of the rheumatic diseases
卷号
70
期号
2
页码范围
349-355
出版商
BMJ Publishing Group Ltd and European League Against Rheumatism
简介
Objectives
Osteoarthritis (OA) is the most prevalent form of arthritis and accounts for substantial morbidity and disability, particularly in older people. It is characterised by changes in joint structure, including degeneration of the articular cartilage, and its aetiology is multifactorial with a strong postulated genetic component.
Methods
A meta-analysis was performed of four genome-wide association (GWA) studies of 2371 cases of knee OA and 35 909 controls in Caucasian populations. Replication of the top hits was attempted with data from 10 additional replication datasets.
Results
With a cumulative sample size of 6709 cases and 44 439 controls, one genome-wide significant locus was identified on chromosome 7q22 for knee OA (rs4730250, p=9.2×10−9), thereby confirming its role as a susceptibility locus for OA.
Conclusion
The associated signal is located within a large (500 kb) linkage disequilibrium block …
学术搜索中的文章
E Evangelou, AM Valdes, HJM Kerkhof, U Styrkarsdottir… - Annals of the rheumatic diseases, 2011