作者
Isabel Ferreiros‐Vidal, Juan J Gomez‐Reino, Francisco Barros, Angel Carracedo, Patricia Carreira, Francisca Gonzalez‐Escribano, Myriam Liz, Javier Martin, Josep Ordi, Jose L Vicario, Antonio Gonzalez
发表日期
2004/8/1
期刊
Arthritis & Rheumatism
卷号
50
期号
8
页码范围
2590-2597
出版商
Wiley Subscription Services, Inc., A Wiley Company
简介
Objective
The A allele of the PD1.3 single‐nucleotide polymorphism (SNP) on the programmed cell death gene PDCD1 was markedly more frequent in patients with systemic lupus erythematosus (SLE) than in unaffected controls in a recent study involving large sets of Swedish, European American, and Mexican families. This study sought to determine the role of PDCD1 in susceptibility to SLE in the Spanish population.
Methods
Seven PDCD1 SNPs were studied in 518 SLE patients and 800 healthy control subjects who had been recruited in 5 distant towns spanning continental Spain. Patients and controls were of Spanish ancestry. The diagnosis of SLE was in accordance with the American College of Rheumatology updated classification criteria.
Results
The A allele of the PD1.3 polymorphism was significantly less frequent in Spanish female patients with SLE than in Spanish female controls (9.0% versus …
引用总数
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I Ferreiros‐Vidal, JJ Gomez‐Reino, F Barros… - Arthritis & Rheumatism: Official Journal of the American …, 2004