作者
Massimo Di Maio, Nicola Lama, Alessandro Morabito, Egbert F Smit, Vassilis Georgoulias, Koji Takeda, Elisabeth Quoix, Dora Hatzidaki, Floris M Wachters, Vittorio Gebbia, Chun-Ming Tsai, Carlos Camps, Wolfgang Schuette, Paolo Chiodini, Maria Carmela Piccirillo, Francesco Perrone, Ciro Gallo, Cesare Gridelli
发表日期
2010/3/1
期刊
European Journal of Cancer
卷号
46
期号
4
页码范围
735-743
出版商
Pergamon
简介
PURPOSE
Knowledge of prognostic factors for advanced non-small-cell lung cancer (NSCLC) patients eligible for second-line treatment is scarce. The aim of this study was to assess the prognostic role of a number of routinely collected clinical variables and to provide a summary index to discriminate patients according to probability of survival.
METHODS
Individual data from nine randomised trials of second-line treatment in advanced NSCLC were analysed. Primary end-point was overall survival (OS). Cox model, stratified by trial, was used for multivariate analyses, and a prognostic index was provided and validated according to an internal/external procedure.
RESULTS
Out of 1239 patients, 1197 patients (97%) had complete information. Median OS was 7.4months. At multivariate analysis, prognosis was significantly influenced by gender (worse in males), performance status (PS), tumour histology (worse in …
学术搜索中的文章
M Di Maio, N Lama, A Morabito, EF Smit… - European Journal of Cancer, 2010