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The number of metastatic axillary nodes represents one of the most important prognostic factors in preoperative breast cancer patients.

^99mTc-Tetrofosmin high resolu tion Pinhole (P)-SPECT was employed in 112patients, 100 with breast cancer and 12 with benign mammary lesions, to ascertain axillary lymph node involvement. Axillary P-SPECT images were acquired utilizing specific software connected to a circular high resolution, single-head gamma camera equipped with apinhole collimator with aperture size of 4.45mm, rotating 180° around the involved axilla. At the same time, patients also underwent conventional SPECT and planar acquisitions.

Per-patient sensitivity and specificity were 100% and 93.6% for P-SPECT, 96.2% and 93.6% for SPECT and 56.6% and 100%for planar imaging, respectively. Moreover, P-SPECT detected more than 51% of lesions ascertained by histology, whereas SPECT and …