作者
Hayley Holt, David A Jolliffe, Mohammad Talaei, Sian Faustini, Giulia Vivaldi, Matthew Greenig, Alex G Richter, Ronan A Lyons, Christopher J Griffiths, Frank Kee, Aziz Sheikh, Gwyneth A Davies, Seif O Shaheen, Adrian R Martineau
发表日期
2023/2/25
期刊
npj Vaccines
卷号
8
期号
1
页码范围
26
出版商
Nature Publishing Group UK
简介
Prospective population-based studies investigating associations between reactive symptoms following SARS-CoV-2 vaccination and serologic responses to vaccination are lacking. We therefore conducted a study in 9003 adults from the UK general population receiving SARS-CoV-2 vaccines as part of the national vaccination programme. Titres of combined IgG/IgA/IgM responses to SARS-CoV-2 spike (S) glycoprotein were determined in eluates of dried blood spots collected from all participants before and after vaccination. 4262 (47.3%) participants experienced systemic reactive symptoms after a first vaccine dose. Factors associating with lower risk of such symptoms included older age (aOR per additional 10 years of age 0.85, 95% CI: 0.81–0.90), male vs. female sex (0.59, 0.53–0.65) and receipt of an mRNA vaccine vs. ChAdOx1 nCoV-19 (0.29, 0.26–0.32 for BNT162b2; 0.06, 0.01–0.26 for mRNA-1273 …
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H Holt, DA Jolliffe, M Talaei, S Faustini, G Vivaldi… - npj Vaccines, 2023