作者
David A Jolliffe, Davaasambuu Ganmaa, Christian Wejse, Rubhana Raqib, M Ahsanul Haq, Nawal Salahuddin, Peter K Daley, Anna P Ralph, Thomas R Ziegler, Adrian R Martineau
发表日期
2019/3/1
期刊
European Respiratory Journal
卷号
53
期号
3
出版商
European Respiratory Society
简介
Background
Randomised controlled trials of adjunctive vitamin D in pulmonary tuberculosis (TB) treatment have yielded conflicting results. Individual participant data meta-analysis could identify factors explaining this variation.
Methods
We meta-analysed individual participant data from randomised controlled trials of vitamin D in patients receiving antimicrobial therapy for pulmonary TB. Primary outcome was time to sputum culture conversion. Secondary outcomes were time to sputum smear conversion, mean 8-week weight and incidence of adverse events. Pre-specified subgroup analyses were done according to baseline vitamin D status, age, sex, drug susceptibility, HIV status, extent of disease and vitamin D receptor genotype.
Results
Individual participant data were obtained for 1850 participants in eight studies. Vitamin D did not influence time to sputum culture conversion overall (adjusted HR 1.06, 95% CI 0.91 …
学术搜索中的文章
DA Jolliffe, D Ganmaa, C Wejse, R Raqib, MA Haq… - European Respiratory Journal, 2019