作者
Ahrin Huh, Michael J Horton, Karen T Cuenco, Gwenael Raoul, Anthea M Rowlerson, Joel Ferri, James J Sciote
发表日期
2013/10/1
期刊
American Journal of Orthodontics and Dentofacial Orthopedics
卷号
144
期号
4
页码范围
568-576
出版商
Mosby
简介
Introduction
Genetic influences on the development of malocclusion include heritable effects on both masticatory muscles and jaw skeletal morphology. Beyond genetic variations, however, the characteristics of muscle and bone are also influenced by epigenetic mechanisms that produce differences in gene expression. We studied 2 enzymes known to change gene expressions through histone modifications, chromatin-modifying histone acetyltransferase KAT6B and deacetylase HDAC4, to determine their associations with musculoskeletal variations in jaw deformation malocclusions.
Methods
Samples of masseter muscle were obtained from subjects undergoing orthognathic surgery from 6 malocclusion classes based on skeletal sagittal and vertical dysplasia. The muscles were characterized for fiber type properties by immunohistochemistry, and their total RNA was isolated for gene expression studies by …
引用总数
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学术搜索中的文章
A Huh, MJ Horton, KT Cuenco, G Raoul, AM Rowlerson… - American Journal of Orthodontics and Dentofacial …, 2013