作者
Toshiaki Ohkuma, Toshiharu Ninomiya, Hirofumi Tomiyama, Kazuomi Kario, Satoshi Hoshide, Yoshikuni Kita, Toyoshi Inoguchi, Yasutaka Maeda, Katsuhiko Kohara, Yasuharu Tabara, Motoyuki Nakamura, Takayoshi Ohkubo, Hirotaka Watada, Masanori Munakata, Mitsuru Ohishi, Norihisa Ito, Michinari Nakamura, Tetsuo Shoji, Charalambos Vlachopoulos, Akira Yamashina, Masahide Nagano, Ogata Yukiyo, Tomoyuki Kabutoya, Kei Asayama, Naoyuki Takashima, Tanvir Turin Chowdhury, Kayo Mitsuki-Shinohara, Takeshi Yamashita
发表日期
2017/6
来源
Hypertension
卷号
69
期号
6
页码范围
1045-1052
出版商
Lippincott Williams & Wilkins
简介
An individual participant data meta-analysis was conducted in the data of 14 673 Japanese participants without a history of cardiovascular disease (CVD) to examine the association of the brachial-ankle pulse wave velocity (baPWV) with the risk of development of CVD. During the average 6.4-year follow-up period, 687 participants died and 735 developed cardiovascular events. A higher baPWV was significantly associated with a higher risk of CVD, even after adjustments for conventional risk factors (P for trend <0.001). When the baPWV values were classified into quintiles, the multivariable-adjusted hazard ratio for CVD increased significantly as the baPWV quintile increased. The hazard ratio in the subjects with baPWV values in quintile 5 versus that in those with the values in quintile 1 was 3.50 (2.14–5.74; P<0.001). Every 1 SD increase of the baPWV was associated with a 1.19-fold (1.10–1.29; P<0.001 …
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T Ohkuma, T Ninomiya, H Tomiyama, K Kario… - Hypertension, 2017