作者
Junko Sato, Akio Kanazawa, Fuki Ikeda, Tomoaki Yoshihara, Hiromasa Goto, Hiroko Abe, Koji Komiya, Minako Kawaguchi, Tomoaki Shimizu, Takeshi Ogihara, Yoshifumi Tamura, Yuko Sakurai, Risako Yamamoto, Tomoya Mita, Yoshio Fujitani, Hiroshi Fukuda, Koji Nomoto, Takuya Takahashi, Takashi Asahara, Takahisa Hirose, Satoru Nagata, Yuichiro Yamashiro, Hirotaka Watada
发表日期
2014/8/1
期刊
Diabetes care
卷号
37
期号
8
页码范围
2343-2350
出版商
American Diabetes Association
简介
OBJECTIVE
Mounting evidence indicates that the gut microbiota are an important modifier of obesity and diabetes. However, so far there is no information on gut microbiota and “live gut bacteria” in the systemic circulation of Japanese patients with type 2 diabetes.
RESEARCH DESIGN AND METHODS
Using a sensitive reverse transcription–quantitative PCR (RT-qPCR) method, we determined the composition of fecal gut microbiota in 50 Japanese patients with type 2 diabetes and 50 control subjects, and its association with various clinical parameters, including inflammatory markers. We also analyzed the presence of gut bacteria in blood samples.
RESULTS
The counts of the Clostridium coccoides group, Atopobium cluster, and Prevotella (obligate anaerobes) were significantly lower (P < 0.05), while the counts of total Lactobacillus (facultative anaerobes …
学术搜索中的文章
J Sato, A Kanazawa, F Ikeda, T Yoshihara, H Goto… - Diabetes care, 2014