作者
Ronald M Sobecks, Tao Wang, Medhat Askar, Meighan M Gallagher, Michael Haagenson, Stephen Spellman, Marcelo Fernandez-Vina, Karl-Johan Malmberg, Carlheinz Müller, Minoo Battiwalla, James Gajewski, Michael R Verneris, Olle Ringdén, Susana Marino, Stella Davies, Jason Dehn, Martin Bornhäuser, Yoshihiro Inamoto, Ann Woolfrey, Peter Shaw, Marilyn Pollack, Daniel Weisdorf, Jeffrey Milller, Carolyn Hurley, Stephanie J Lee, Katharine Hsu
发表日期
2015/9/1
期刊
Biology of Blood and Marrow Transplantation
卷号
21
期号
9
页码范围
1589-1596
出版商
Elsevier
简介
Natural killer cells are regulated by killer cell immunoglobulin-like receptor (KIR) interactions with HLA class I ligands. Several models of natural killer cell reactivity have been associated with improved outcomes after myeloablative allogeneic hematopoietic cell transplantation (HCT), but this issue has not been rigorously addressed in reduced-intensity conditioning (RIC) unrelated donor (URD) HCT. We studied 909 patients undergoing RIC-URD HCT. Patients with acute myeloid leukemia (AML, n = 612) lacking ≥ 1 KIR ligands experienced higher grade III to IV acute graft-versus-host disease (GVHD) (HR, 1.6; 95% CI, 1.16 to 2.28; P = .005) compared to those with all ligands present. Absence of HLA-C2 for donor KIR2DL1 was associated with higher grade II to IV (HR, 1.4; P = .002) and III to IV acute GVHD (HR, 1.5; P = .01) compared with HLA-C2+ patients. AML patients with KIR2DS1+, HLA-C2 homozygous …
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RM Sobecks, T Wang, M Askar, MM Gallagher… - Biology of Blood and Marrow Transplantation, 2015
