作者
Ramanathan K Kasimanickam, Vanmathy R Kasimanickam, Jacobo S Rodriguez, Kevin D Pelzer, Philip D Sponenberg, Craig D Thatcher
发表日期
2010/12
期刊
Reproductive Biology and Endocrinology
卷号
8
页码范围
1-11
出版商
BioMed Central
简介
Background
Tocopherols have biphasic, proangiogenic and antiangiogenic therapeutic effects. The objective of this clinical trial was to clarify tocopherol's placental angiogenic potential in late pregnant ewes following oral supplementation.
Methods
Eighteen pregnant ewes during late gestation were selected for this study. Ewes were given oral supplementation of 500 mg of alpha-tocopherol (aT; N = 6) or 1000 mg of gamma-tocopherol (gT; N = 7) or placebo (CON; N = 5) once daily from 107 to 137 days post breeding. Serum was obtained at weekly intervals and tissue samples were obtained at the end of supplementation to: 1) evaluate tocopherol concentrations in serum, uterus and placentome; 2) evaluate relative mRNA expressions of Vascular Endothelial Growth Factor (VEGF), Placental Growth Factor (PlGF), endothelial Nitric Oxide Synthase …
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RK Kasimanickam, VR Kasimanickam, JS Rodriguez… - Reproductive Biology and Endocrinology, 2010