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OBJECTIVE: To review different methods for artificial oocyte activation and its impact on intracytoplasmic sperm injection (ICSI). DESIGN: Literature review. SETTING: University-based and university-affiliated medical centers. PATIENT(S): None. INTERVENTION(S): Literature search in Entrez PubMed as well as other data sources. MAIN OUTCOME MEASURE(S): None. RESULT(S): The ICSI procedure improves fertilization rates in cases of male factor infertility; however, fertilization failure still occurs in 2% to 3% of ICSI cycles. The main cause of failed fertilization is failure to complete oocyte activation. The investigators do not use a variety of mechanical, electrical, and chemical methods to mimic the calcium rise necessary to activate oocytes after ICSI. Chemical activation is the most commonly used method for artificial oocyte activation, resulting in high fertilization rates. CONCLUSION(S): Artificial oocyte activation …