作者
Dániel Aradi, Ajay Kirtane, Laurent Bonello, Paul A Gurbel, Udaya S Tantry, Kurt Huber, Matthias K Freynhofer, Jurrien Ten Berg, Paul Janssen, Dominick J Angiolillo, Jolanta M Siller-Matula, Rossella Marcucci, Giuseppe Patti, Fabio Mangiacapra, Marco Valgimigli, Olivier Morel, Tullio Palmerini, Matthew J Price, Thomas Cuisset, Adnan Kastrati, Gregg W Stone, Dirk Sibbing
发表日期
2015/7/14
来源
European heart journal
卷号
36
期号
27
页码范围
1762-1771
出版商
Oxford University Press
简介
Aims
Although platelet reactivity during P2Y12-inhibitors is associated with stent thrombosis (ST) and bleeding, standardized and clinically validated thresholds for accurate risk stratification after percutaneous coronary intervention (PCI) are lacking. We sought to determine the prognostic value of low platelet reactivity (LPR), optimal platelet reactivity (OPR), or high platelet reactivity (HPR) by applying uniform cut-off values for standardized devices.
Methods and results
Authors of studies published before January 2015, reporting associations between platelet reactivity, ST, and major bleeding were contacted for a collaborative analysis using consensus-defined, uniform cut-offs for standardized platelet function assays. Based on best available evidence for each device (exploratory studies), LPR–OPR–HPR categories were defined as <95, 95–208, and >208 PRU for VerifyNow …
学术搜索中的文章
D Aradi, A Kirtane, L Bonello, PA Gurbel, US Tantry… - European heart journal, 2015