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Objectives:

Systemic inflammatory response occurs frequently after coronary artery bypass surgery, and it is strongly correlated with the risk of postoperative morbidity and mortality. Recent studies demonstrate that treatment with statin is associated with a significant and marked decrease in inflammation-associated variables such as the C-reactive protein, cytokines, and adhesion molecules. Therefore, we investigated the effects of preoperative atorvastatin treatment on systemic inflammatory response and perioperative morbidity after cardiopulmonary bypass.

Design:

Double-blinded, placebo-controlled, randomized study.

Setting:

University hospital.

Patients:

Forty patients were randomized to treatment with atorvastatin (20 mg/day, group A, n= 20) or placebo (group B, n= 20) 3 wks before surgery.

Interventions:

Three-week treatment by atorvastatin 20 mg/day.

Measurement and Main Results:

Postoperative serum levels …