作者
Germano Di Sciascio, Giuseppe Patti, Vincenzo Pasceri, Achille Gaspardone, Giuseppe Colonna, Antonio Montinaro
发表日期
2009/8/4
期刊
Journal of the American College of Cardiology
卷号
54
期号
6
页码范围
558-565
出版商
American College of Cardiology Foundation
简介
Objectives
This study was designed to investigate whether an acute atorvastatin reload before percutaneous coronary intervention (PCI) protects patients receiving chronic statin therapy from periprocedural myocardial damage.
Background
Previous ARMYDA (Atorvastatin for Reduction of Myocardial Damage During Angioplasty) studies demonstrated that short-term pre-treatment with atorvastatin reduces myocardial infarction during PCI in statin-naïve patients with both stable angina and acute coronary syndromes.
Methods
A total of 383 patients (age 66 ± 10 years, 305 men) with stable angina (53%) or non–ST-segment elevation acute coronary syndromes (47%) and chronic statin therapy (55% atorvastatin) undergoing PCI were randomized to atorvastatin reload (80 mg 12 h before intervention, with a further 40-mg pre-procedural dose [n = 192]) or placebo (n = 191). All patients received long-term atorvastatin …
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G Di Sciascio, G Patti, V Pasceri, A Gaspardone… - Journal of the American College of Cardiology, 2009