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Nowadays, one important challenge in cyber-physical production systems is updating dynamic production schedules through an automated decision-making performed while the production is running. The condition of the manufacturing equipment may in fact lead to schedule unfeasibility or inefficiency, thus requiring responsiveness to preserve productivity and reduce the operational costs. In order to address current limitations of traditional scheduling methods, this work proposes a new framework that exploits the aggregation of several digital twins, representing different physical assets and their autonomous decision-making, together with a global digital twin, in order to perform production scheduling optimization when it is needed. The decision-making process is supported on a fuzzy inference system using the state or conditions of different assets and the production rate of the whole system. The condition of the …