作者
Dag Alnæs, Tobias Kaufmann, Nhat Trung Doan, Aldo Córdova-Palomera, Yunpeng Wang, Francesco Bettella, Torgeir Moberget, Ole A Andreassen, Lars T Westlye
发表日期
2018/3/1
期刊
JAMA psychiatry
卷号
75
期号
3
页码范围
287-295
出版商
American Medical Association
简介
Importance
Many mental disorders emerge during adolescence, which may reflect a cost of the potential for brain plasticity offered during this period. Brain dysconnectivity has been proposed as a common factor across diagnostic categories.
Objective
To investigate the hypothesis that brain dysconnectivity is a transdiagnostic phenotype in adolescence with increased susceptibility and symptoms of psychiatric disease.
Design, Setting, and Participants
We investigated clinical symptoms as well as cognitive function in 6487 individuals aged 8 to 21 years from November 1, 2009, to November 30, 2011, in the Philadelphia Neurodevelopmental Cohort and analyzed diffusion magnetic resonance imaging brain scans for 748 of the participants.
Main Outcomes and Measures
Independent component analysis was used to derive dimensional psychopathology scores, and genome-wide complex trait analysis was used to …
学术搜索中的文章
D Alnæs, T Kaufmann, NT Doan, A Córdova-Palomera… - JAMA psychiatry, 2018