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The aim of the current study was to analyse in two age cohorts the presence of mediation effects of parenting practices (i.e., parental knowledge, parental support, parent-adolescent conflict) through deviant peers on youth antisocial behaviour (i.e., nonviolent antisocial behaviour, violent behaviour). The final sample was subdivided in a younger group (n = 377), aged 14 to 16 (M = 15.27, SD = 0.72), 45.9% males, and an older group (n = 206), aged 17 to 19 (M = 17.30, SD = 0.54), 48.5% males. The structural equation modelling results indicated significant mediation effects for both age cohorts. Family factors presented more influence for younger adolescents, whereas deviant peers showed more influence for older adolescents. The findings also indicated the reciprocal influence of selection and socialisation processes suggesting the need of early interventions for preventing the development of antisocial behaviour.