作者
Luca Valerio, Anna C Mavromanoli, Stefano Barco, Christina Abele, Dorothea Becker, Leonhard Bruch, Ralf Ewert, Martin Faehling, David Fistera, Felix Gerhardt, Hossein Ardeschir Ghofrani, Aleksandar Grgic, Ekkehard Grünig, Michael Halank, Matthias Held, Lukas Hobohm, Marius M Hoeper, Frederikus A Klok, Mareike Lankeit, Hanno H Leuchte, Nadine Martin, Eckhard Mayer, F Joachim Meyer, Claus Neurohr, Christian Opitz, Kai Helge Schmidt, Hans Jürgen Seyfarth, Rolf Wachter, Heinrike Wilkens, Philipp S Wild, Stavros V Konstantinides, Stephan Rosenkranz
发表日期
2022/9/21
期刊
European Heart Journal
卷号
43
期号
36
页码范围
3387-3398
出版商
Oxford University Press
简介
Aims
To systematically assess late outcomes of acute pulmonary embolism (PE) and to investigate the clinical implications of post-PE impairment (PPEI) fulfilling prospectively defined criteria.
Methods and results
A prospective multicentre observational cohort study was conducted in 17 large-volume centres across Germany. Adult consecutive patients with confirmed acute symptomatic PE were followed with a standardized assessment plan and pre-defined visits at 3, 12, and 24 months. The co-primary outcomes were (i) diagnosis of chronic thromboembolic pulmonary hypertension (CTEPH), and (ii) PPEI, a combination of persistent or worsening clinical, functional, biochemical, and imaging parameters during follow-up. A total of 1017 patients (45% women, median age 64 years) were included in the primary analysis. They were followed for a median duration of 732 days after …
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L Valerio, AC Mavromanoli, S Barco, C Abele… - European Heart Journal, 2022