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d -glucosamine at concentration of certain range could kill tumor cells without influencing normal cells. There are also some reports on the antitumor activity of d -glucosamine and its derivatives in murine models. It was therefore postulated that d -glucosamine might have the potential to invade tumor cells. We designed and radiosynthesized a glucosamine derivative, N -(2-[ ¹⁸ F]fluoro-4-nitrobenzoyl)glucosamine ([ ¹⁸ F]FNBG([ ¹⁸ F]7)). Evaluations in vitro and in vivo were performed on tumor bearing mice. Excitingly, the radiochemical purity of [ ¹⁸ F]FNBG([ ¹⁸ F]7) was 99%, and besides the best radiochemical yield was up to 35%. The best T/Bl (Tumor/Blood) and T/M (Tumor/Muscle) ratios of [ ¹⁸ F]FNBG([ ¹⁸ F]7) were 4.40 and 4.84. Although [ ¹⁸ …