作者
Benjamin Kasenda, Andrés JM Ferreri, E Marturano, Deborah Forst, Jacoline Bromberg, H Ghesquieres, C Ferlay, Jean Yves Blay, Khê Hoang-Xuan, EJ Pulczynski, A Fosså, Y Okoshi, Shigeru Chiba, Kristina Fritsch, A Omuro, BP O'Neill, O Bairey, S Schandelmaier, V Gloy, N Bhatnagar, S Haug, S Rahner, TT Batchelor, Gerald Illerhaus, M Briel
发表日期
2015/7/1
来源
Annals of Oncology
卷号
26
期号
7
页码范围
1305-1313
出版商
Elsevier
简介
Background
To investigate prognosis and effects of first-line therapy in elderly primary central nervous system lymphoma (PCNSL) patients.
Patients and methods
A systematic review of studies about first-line therapy in immunocompetent patients ≥60 years with PCNSL until 2014 and a meta-analysis of individual patient data from eligible studies and international collaborators were carried out.
Results
We identified 20 eligible studies; from 13 studies, we obtained individual data of 405 patients, which were pooled with data of 378 additional patients (N = 783). Median age and Karnofsky Performance Score (KPS) was 68 years (range: 60–90 years) and 60% (range: 10%–100%), respectively. Treatments varied greatly, 573 (73%) patients received high-dose methotrexate (HD-MTX)-based therapy. A total of 276 patients received whole-brain radiotherapy (median 36 Gy, range 28.5–70 Gy). KPS ≥ 70% was the …
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B Kasenda, AJM Ferreri, E Marturano, D Forst… - Annals of Oncology, 2015