作者
Carmilla MM Licht, Eco JC de Geus, Frans G Zitman, Witte JG Hoogendijk, Richard van Dyck, Brenda WJH Penninx
发表日期
2008/12/1
期刊
Archives of general psychiatry
卷号
65
期号
12
页码范围
1358-1367
出版商
American Medical Association
简介
Context
It has been hypothesized that depression is associated with lower heart rate variability and decreased cardiac vagal control. This may play an important role in the risk of cardiovascular disease among depressed individuals.
Objective
To determine whether heart rate variability was lower in depressed individuals than in healthy controls in a large adult sample.
Design
Cross-sectional analyses from a large depression cohort study.
Setting
The Netherlands Study of Depression and Anxiety.
Participants
Two thousand three hundred seventy-three individuals (mean age, 41.8 years; 66.8% female) who participated in the Netherlands Study of Depression and Anxiety. Included were 524 controls, 774 individuals with a diagnosis of major depressive disorder (MDD) earlier in life (remitted MDD), and 1075 individuals with current MDD based on the Composite International Diagnostic Interview. This sample was …
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