作者
Maria Sepúlveda, Thaís Armangué, Nuria Sola-Valls, Georgina Arrambide, José E Meca-Lallana, Celia Oreja-Guevara, Mar Mendibe, Amaya Alvarez de Arcaya, Yolanda Aladro, Bonaventura Casanova, Javier Olascoaga, Adolfo Jiménez-Huete, Mireya Fernández-Fournier, Lluis Ramió-Torrentà, Alvaro Cobo-Calvo, Montserrat Viñals, Clara De Andrés, Virginia Meca-Lallana, Angeles Cervelló, Carmen Calles, Manuel Barón Rubio, Cristina Ramo-Tello, Ana Caminero, Elvira Munteis, Alfredo R Antigüedad, Yolanda Blanco, Pablo Villoslada, Xavier Montalban, Francesc Graus, Albert Saiz, Spanish NMO Study Group, Laura Borrego, Francisco José J Villaverde, Ángel P Sempere, Luis Brieva, Macarena Bonet, Montserrat González-Platas, Delon La Puma, Sara Llufriu, Eugenia H Martínez, Sabas Boyero, Julián Benito-León, Juan C López, René Robles, Jesús Foronda, Laura Navarró, Tomás Millán, Miguel Hervás, Antonio Tallón, Inmaculada Puertas, Nuria Huertas, Laura Redondo, Sonia Santos, Itziar Palmí, Mónica Salgado, José E Martínez, Miguel A Rubio, Agustín Oterino, Ramón Ara, Ramón Villaverde, Teresa Ayuso, Elena Erro, Miquel Marco, Luisa Villar, José C Álvarez-Cermeño, Eduardo Agüera, Enrique Bescansa, Isabel Yugüeros, Miguel A Tola, Aida Orviz-García, Tomás del Haro, María Bestué, Monserrat Gómez, Luis Querol, Elena Rodríguez, Jordi Ballabriga, Mar Tintoré, Joaquin Castilló, Jordi Rio, Delicias Muñoz, Luciana Midaglia, Ester Carreón-Guarnizo, José L Casado, Antonio Uclés, Rosa García-Montero
发表日期
2016/4/14
期刊
Neuroimmunology & Neuroinflammation
卷号
3
期号
3
页码范围
e225
出版商
Lippincott Williams & Wilkins
简介
Objective
To (1) determine the value of the recently proposed criteria of neuromyelitis optica (NMO) spectrum disorder (NMOSD) that unify patients with NMO and those with limited forms (NMO/LF) with aquaporin-4 immunoglobulin G (AQP4-IgG) antibodies; and (2) investigate the clinical significance of the serologic status in patients with NMO.
Methods
This was a retrospective, multicenter study of 181 patients fulfilling the 2006 NMO criteria (n = 127) or NMO/LF criteria with AQP4-IgG (n = 54). AQP4-IgG and myelin oligodendrocyte glycoprotein immunoglobulin G (MOG-IgG) antibodies were tested using cell-based assays.
Results
Patients were mainly white (86%) and female (ratio 6.5:1) with median age at onset 39 years (range 10–77). Compared to patients with NMO and AQP4-IgG (n = 94), those with NMO/LF presented more often with longitudinally extensive transverse myelitis (LETM) (p < 0.001), and had lower …
学术搜索中的文章
M Sepúlveda, T Armangué, N Sola-Valls, G Arrambide… - Neuroimmunology & Neuroinflammation, 2016