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After the 30-day experiment, all animals were sacrificed, and samples from liver tissues and bile ducts were collected for p53 gene expression (P53GE), using real time PCR (RT-PCR), and histopathological tests.[...] CdCl2 induces detrimental toxic effects shown via the histopathological changes in the liver and the bile duct tissues. MATERIALS AND METHODS Animals and Experimental design Here, 12 Wistar male and female rats, 200-220gm, were purchased from the animal housing in the College of Veterinary Medicine, University of Al-Qadisiyah, Diwaniyah, Iraq. For the genetic-based changes,(19) indicated that exposure to Cd at 50mg for 12 weeks induced compact of chromatin.[...] liver cell cytoplasm became light, and trabecular structure was blurred, foamy and vacuolated.[...] CdCl2 induces detrimental toxic effects shown via the histopathological changes in the liver and the bile duct tissues.