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Objective: We present our experience with the endoscopic transcortical-transventricular approach (ETTA) as an option for new or recurrent cases of CP located in the third ventricle.

Methods: Data for third ventricular craniopharyngiomas treated via ETTA in two tertiary medical centers from 2006 to 2020 were retrospectively reviewed. Cystic and mixed lesions, as well as new and recurrent cases, were included. ETTA aimed at cyst fenestration, subtotal or partial tumor resection, managing the hydrocephalus, or a combination of these modalities. Fractionated radiotherapy (RT) was performed using a target delivered dose of 54 Gy in 30 fractions.

Results: By reviewing our database, 44 CP patients that were operated on in both departments were identified. The described approach was performed in 13 patients with a mean age of 30.2 years (range 5-84). ETTA was done in 7 newly diagnosed patients and in 6 patients at …