作者
Sunita Sharma, Xiaobo Zhou, Derek M Thibault, Blanca E Himes, Andy Liu, Stanley J Szefler, Robert Strunk, Mario Castro, Nadia N Hansel, Gregory B Diette, Becky M Vonakis, N Franklin Adkinson Jr, Lydiana Avila, Manuel Soto-Quiros, Albino Barraza-Villareal, Robert F Lemanske Jr, Julian Solway, Jerry Krishnan, Steven R White, Chris Cheadle, Alan E Berger, Jinshui Fan, Meher Preethi Boorgula, Dan Nicolae, Frank Gilliland, Kathleen Barnes, Stephanie J London, Fernando Martinez, Carole Ober, Juan C Celedón, Vincent J Carey, Scott T Weiss, Benjamin A Raby
发表日期
2014/11/1
期刊
Journal of allergy and clinical immunology
卷号
134
期号
5
页码范围
1153-1162
出版商
Mosby
简介
Background
Genome-wide association studies have yet to identify the majority of genetic variants involved in asthma. We hypothesized that expression quantitative trait locus (eQTL) mapping can identify novel asthma genes by enabling prioritization of putative functional variants for association testing.
Objective
We evaluated 6706 cis-acting expression-associated variants (eSNPs) identified through a genome-wide eQTL survey of CD4+ lymphocytes for association with asthma.
Methods
eSNPs were tested for association with asthma in 359 asthmatic patients and 846 control subjects from the Childhood Asthma Management Program, with verification by using family-based testing. Significant associations were tested for replication in 579 parent-child trios with asthma from Costa Rica. Further functional validation was performed by using formaldehyde-assisted isolation of regulatory elements (FAIRE) quantitative …
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S Sharma, X Zhou, DM Thibault, BE Himes, A Liu… - Journal of allergy and clinical immunology, 2014