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Objective:

Volume depletion and/or increased hematocrit are associated with poor prognosis in necrotizing pancreatitis. Several studies suggest that intrathoracic blood volume index (ITBI) might be superior to central venous pressure (CVP) with regard to preload assessment. Therefore, the aim of our study was to evaluate the predictive value of CVP and hematocrit with regard to ITBI, and to correlate these parameters to cardiac index (CI).

Design:

Prospective study.

Setting:

Medical intensive care unit, university hospital.

Patients and Interventions:

Within 24 hrs of intensive care unit-admission, 96 hemodynamic measurements using the PiCCO system were performed in 24 patients with necrotizing pancreatitis.

Main Results:

Mean CVP (12.11±5.97 mm Hg; median 11.5 normal: 1–9 mm Hg) was elevated, whereas mean ITBI (822.8±157.0 mL/m 2; median 836 mL/m 2; normal: 850–1000 mL/m 2) was decreased. Fifty …