查看文章

Aquaculture is expanding due to the high demand of fish for human consumption. However, since carnivorous fish are fed using fish-derived proteins and lipids, the sustainability of this food-producing sector is debated. Therefore, feed industries and academia are dedicating their efforts to the search for suitable raw materials and more sustainable alternative feeds that are able to ensure the health of the fish. To properly evaluate the effect of these feed formulations, extensive knowledge of the intestinal morphology and physiology is required. Moreover, the intestine is a dynamic environment in which homeostasis is controlled by highly specialized intestinal stem-cell niches. These defined functional units consist of epithelial stem cells, the supportive mesenchymal cell population, and acellular components. While they have been widely studied in the mouse intestine, this understanding is almost absent in fish species. We have previously characterized the organization of the stem-cell niche in the rainbow trout intestine; here, we expand that knowledge by examining telocytes as active stromal components of the niche. Our results indicate that this cell type is also present in rainbow trout and that it represents a key mediator of intestinal homeostasis by virtue of its active interaction with the stem cells.

In order to improve the sustainability of trout farming, it is essential to develop alternatives to fish-based meals that prevent intestinal disorders and support growth performances. Therefore, an accurate knowledge of intestinal morphology and physiology is desirable. We previously described the …