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The purpose of this study was to investigate the effect of online mindfulness program (MR) on physical pain, stress and depression in COVID-19 patients. Forty COVID-19 patients (F= 20, M= 20) were randomly selected and divided into experimental (n= 20) and control (n= 20) groups with an age range of 20-45 years. Physical pain (via the Visual Analogue Scale (VAS)) and psychological wellbeing (via Perceived Stress Scale (PSS) and Beck depression inventory II (BDI)) were assessed prior to and following a two week online MR. All patients completed the two week online MR and no adverse events were reported over the intervention period. In the online MR, all sub-components of the PASS and BDI were improved (all P< 0.05) and also scales related to physical pain was decreased which showed an overall improvement in stress (z=-3.83, P=. 001), depression (z=-3.92, P=. 001) and physical pain (z=-3.86, P …