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Stress is one of the main causes that increase the risk of serious health problems. Recent wearable devices have been used to monitor stress levels via electrodermal activities on the skin. Although many biosensors provide adequate sensing performance, they still rely on uncomfortable, partially flexible systems with rigid electronics. These devices are mounted on either fingers or palms, which hinders a continuous signal monitoring. A fully‐integrated, stretchable, wireless skin‐conformal bioelectronic (referred to as “SKINTRONICS”) is introduced here that integrates soft, multi‐layered, nanomembrane sensors and electronics for continuous and portable stress monitoring in daily life. The all‐in‐one SKINTRONICS is ultrathin, highly soft, and lightweight, which overall offers an ergonomic and conformal lamination on the skin. Stretchable nanomembrane electrodes and a digital temperature sensor enable highly …