作者
Daniele Regge, Cristiana Laudi, Giovanni Galatola, Patrizia Della Monica, Luigina Bonelli, Giuseppe Angelelli, Roberto Asnaghi, Brunella Barbaro, Carlo Bartolozzi, Didier Bielen, Luca Boni, Claudia Borghi, Paolo Bruzzi, Maria Carla Cassinis, Massimo Galia, Teresa Maria Gallo, Andrea Grasso, Cesare Hassan, Andrea Laghi, Maria Cristina Martina, Emanuele Neri, Carlo Senore, Giovanni Simonetti, Silvia Venturini, Giovanni Gandini
发表日期
2009/6/17
期刊
Jama
卷号
301
期号
23
页码范围
2453-2461
出版商
American Medical Association
简介
Context
Computed tomographic (CT) colonography has been recognized as an alternative for colorectal cancer (CRC) screening in average-risk individuals, but less information is available on its performance in individuals at increased risk of CRC.
Objective
To assess the accuracy of CT colonography in detecting advanced colorectal neoplasia in asymptomatic individuals at increased risk of CRC using unblinded colonoscopy as the reference standard.
Design, Setting, and Participants
This was a multicenter, cross-sectional study. Individuals at increased risk of CRC due to either family history of advanced neoplasia in first-degree relatives, personal history of colorectal adenomas, or positive results from fecal occult blood tests (FOBTs) were recruited in 11 Italian centers and 1 Belgian center between December 2004 and May 2007. Each participant underwent CT colonography followed by colonoscopy on the same …
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D Regge, C Laudi, G Galatola, P Della Monica… - Jama, 2009