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Rats with simple incised wounds of the telencephalon were treated for either 7 or 50 days with either sunthetic corticotrophin (ACTH) or triiodothyronine (T3). Control animals received no treatment. Regenerating axons, which entered and sometimes crossed the lesions, were detected histologically in rats treated with both hormones. The effects of both ACTH and T3 were mediated during the first 7 days after placement of the lesion. We suggest that ACTH, in suitable dosage, acts by allowing the formation of a suitable type of loose connective tissue in the lesion, while T3 increases the rate of synthesis of axoplasmic structural protein.