作者
Bart Janssen, Daniela Hohenadel, Paul Brinkkoetter, Verena Peters, Nina Rind, Christine Fischer, Ivan Rychlik, Marie Cerna, Marianna Romzova, Emile de Heer, Hans Baelde, Stephan JL Bakker, Mahmoud Zirie, Eric Rondeau, Peter Mathieson, Moin A Saleem, Jochen Meyer, Hannes Koppel, Sibylle Sauerhoefer, Claus R Bartram, Peter Nawroth, Hans-Peter Hammes, Benito A Yard, Johannes Zschocke, Fokko J van der Woude
发表日期
2005/8/1
期刊
Diabetes
卷号
54
期号
8
页码范围
2320-2327
出版商
American Diabetes Association
简介
The risk of diabetic nephropathy is partially genetically determined. Diabetic nephropathy is linked to a gene locus on chromosome 18q22.3-q23. We aimed to identify the causative gene on chromosome 18 and to study the mechanism by which the product of this gene could be involved in the development of diabetic nephropathy. DNA polymorphisms were determined in 135 case (diabetic nephropathy) and 107 control (diabetes without nephropathy) subjects. The effect of carnosine on the production of extracellular matrix components and transforming growth factor-β (TGF-β) after exposure to 5 and 25 mmol/l d-glucose was studied in cultured human podocytes and mesangial cells, respectively. A trinucleotide repeat in exon 2 of the CNDP1 gene, coding for a leucine repeat in the leader peptide of the carnosinase-1 precursor, was associated with nephropathy. The shortest allelic form (CNDP1 Mannheim) was …
引用总数
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B Janssen, D Hohenadel, P Brinkkoetter, V Peters… - Diabetes, 2005