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Genetic Programming has been used to determine Chèzy resistance coefficient for full circular corrugated channels. Three corrugated plastic pipes have been experimentally studied in order to generate data. The tests aim at measuring hydraulic parameters of the open-channel flow for some slopes, from 3.49–17.37% (2–10°), in order to discover the dependence of the channel resistance coefficient when wake-interference flow occurs. The monomial formula for the Chèzy resistance coefficient performs well on experimental data, both from measurement errors and from a technical point of view. In this paper, we present some very parsimonious formulae that have been created by Genetic Programming with few constants and which fit the data better than the monomial formula. Moreover, two of the Genetic Programming formulae, after ‘physical post-refinement’, seem to better explain the role of the roughness in the …