作者
Richard Sherva, Rui Zhang, Nathan Sahelijo, Gyungah Jun, Tori Anglin, Catherine Chanfreau, Kelly Cho, Jennifer R Fonda, J Michael Gaziano, Kelly M Harrington, Yuk-Lam Ho, William S Kremen, Elizabeth Litkowski, Julie Lynch, Zoe Neale, Panos Roussos, David Marra, Jesse Mez, Mark W Miller, David H Salat, Debby Tsuang, Erika Wolf, Qing Zeng, Matthew S Panizzon, Victoria C Merritt, Lindsay A Farrer, Richard L Hauger, Mark W Logue
发表日期
2023/3
期刊
Molecular psychiatry
卷号
28
期号
3
页码范围
1293-1302
出版商
Nature Publishing Group UK
简介
While genome wide association studies (GWASs) of Alzheimer’s Disease (AD) in European (EUR) ancestry cohorts have identified approximately 83 potentially independent AD risk loci, progress in non-European populations has lagged. In this study, data from the Million Veteran Program (MVP), a biobank which includes genetic data from more than 650,000 US Veteran participants, was used to examine dementia genetics in an African descent (AFR) cohort. A GWAS of Alzheimer’s disease and related dementias (ADRD), an expanded AD phenotype including dementias such as vascular and non-specific dementia that included 4012 cases and 18,435 controls age 60+ in AFR MVP participants was performed. A proxy dementia GWAS based on survey-reported parental AD or dementia (n = 4385 maternal cases, 2256 paternal cases, and 45,970 controls) was also performed. These two GWASs were meta …
学术搜索中的文章
R Sherva, R Zhang, N Sahelijo, G Jun, T Anglin… - Molecular psychiatry, 2023