作者
Richelle D Björvang, Ida Hallberg, Anne Pikki, Lars Berglund, Matteo Pedrelli, Hannu Kiviranta, Panu Rantakokko, Päivi Ruokojärvi, Christian H Lindh, Matts Olovsson, Sara Persson, Jan Holte, Ylva Sjunnesson, Pauliina Damdimopoulou
发表日期
2022/5/15
期刊
Environmental Research
卷号
208
页码范围
112626
出版商
Academic Press
简介
Persistent organic pollutants (POPs) are industrial chemicals resistant to degradation and have been shown to have adverse effects on reproductive health in wildlife and humans. Although regulations have reduced their levels, they are still ubiquitously present and pose a global concern. Here, we studied a cohort of 185 women aged 21–43 years with a median of 2 years of infertility who were seeking assisted reproductive technology (ART) treatment at the Carl von Linné Clinic in Uppsala, Sweden. We analyzed the levels of 9 organochlorine pesticides (OCPs), 10 polychlorinated biphenyls (PCBs), 3 polybrominated diphenyl ethers (PBDEs), and 8 perfluoroalkyl substances (PFASs) in the blood and follicular fluid (FF) samples collected during ovum pick-up. Impact of age on chemical transfer from blood to FF was analyzed. Associations of chemicals, both individually and as a mixture, to 10 ART endpoints were …
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