作者
Brian D Ross, Bradford A Moffat, Theodore S Lawrence, Suresh K Mukherji, Stephen S Gebarski, Douglas J Quint, Timothy D Johnson, Larry Junck, Patricia L Robertson, Karin M Muraszko, Qian Dong, Charles R Meyer, Peyton H Bland, Patrick McConville, Hairong Geng, Alnawaz Rehemtulla, Thomas L Chenevert
发表日期
2003/6/1
来源
Molecular cancer therapeutics
卷号
2
期号
6
页码范围
581-587
出版商
American Association for Cancer Research
简介
Assessment of the effectiveness of cancer therapy traditionally relies on comparison of tumor images acquired before and after therapeutic intervention by inspection of gross anatomical images to evaluate changes in tumor size. The potential for imaging to provide additional insights related to the therapeutic impact would be enhanced if a specific parameter or combination of parameters could be identified that reflect tissue changes at the cellular or physiological level. This information could also provide a more sensitive and earlier indicator of treatment response in an individual animal or patient. Diffusion magnetic resonance imaging can detect relatively small changes in tissue structure at the cellular level and thus provides an opportunity to quantitatively and serially follow therapeutic-induced changes in solid tumors. This article provides an overview of the use of diffusion magnetic resonance imaging as a …
引用总数
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BD Ross, BA Moffat, TS Lawrence, SK Mukherji… - Molecular cancer therapeutics, 2003