作者
Arul M Chinnaiyan, Uttara Prasad, Sunita Shankar, Daniel A Hamstra, Murthy Shanaiah, Thomas L Chenevert, Brian D Ross, Alnawaz Rehemtulla
发表日期
2000/2/15
期刊
Proceedings of the National Academy of Sciences
卷号
97
期号
4
页码范围
1754-1759
出版商
The National Academy of Sciences
简介
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a potent endogenous activator of the cell death pathway and functions by activating the cell surface death receptors 4 and 5 (DR4 and DR5). TRAIL is nontoxic in vivo and preferentially kills neoplastically transformed cells over normal cells by an undefined mechanism. Radiotherapy is a common treatment for breast cancer as well as many other cancers. Here we demonstrate that ionizing radiation can sensitize breast carcinoma cells to TRAIL-induced apoptosis. This synergistic effect is p53-dependent and may be the result of radiation-induced up-regulation of the TRAIL-receptor DR5. Importantly, TRAIL and ionizing radiation have a synergistic effect in the regression of established breast cancer xenografts. Changes in tumor cellularity and extracellular space were monitored in vivo by diffusion-weighted magnetic resonance imaging (diffusion …
引用总数
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AM Chinnaiyan, U Prasad, S Shankar, DA Hamstra… - Proceedings of the National Academy of Sciences, 2000