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Diabetic wound healing remains a critical challenge due to its vulnerability to multidrug-resistant (MDR) bacterial infection, as well as the hyperglycemic and oxidative wound microenvironment. Herein, an injectable multifunctional hydrogel (FEMI) was developed to simultaneously overcome these hurdles. The FEMI hydrogel was fabricated through a Schiff-based reaction between ε-polylysine (EPL)-coated MnO₂ nanosheets (EM) and insulin-loaded self-assembled aldehyde Pluronic F127 (FCHO) micelles. Through a synergistic combination of EPL and “nanoknife-like” MnO₂ nanosheets, the FEMI hydrogel exhibited extraordinary antimicrobial capacities against MDR bacteria. The MnO₂ nanoenzyme reshaped the hostile oxidative wound microenvironment by decomposing the endogenous H₂O₂ into O₂. Meanwhile, the pH/redox dual-responsive FEMI hydrogel achieved a sustained and spatiotemporal …